1. Tragedy and delight: the ethics of decelerated ageing - PMC - NCBI
Current research on the biology of ageing suggests that there is a reasonable possibility that treatments that decelerate human ageing could be developed, given ...
Biogerontology is sometimes viewed as similar to other forms of biomedical research in that it seeks to understand and treat a pathological process. Yet the prospect of treating ageing is extraordinary in terms of the profound changes to the human condition ...
2. Interventions to Slow Aging in Humans: Are We Ready? - NCBI
Missing: decelerating | Show results with:decelerating
The workshop entitled ‘Interventions to Slow Aging in Humans: Are We Ready?’ was held in Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus related ...
3. [PDF] International Nuclear Power Plant Aging Symposium
Abstract. This report presents the proceedings of the nternational. Nuclear Power Plant Aging Symposium that was held at the.
4. Epigenetics of Aging and Alzheimer's Disease: Implications for ... - MDPI
Interventions targeting epigenetic regulation might be effective in treating a range of age-related neurodegenerative disorders [8,9]. The downstream synaptic ...
Epigenetic variability (DNA methylation/demethylation, histone modifications, microRNA regulation) is common in physiological and pathological conditions. Epigenetic alterations are present in different tissues along the aging process and in neurodegenerative disorders, such as Alzheimer’s disease (AD). Epigenetics affect life span and longevity. AD-related genes exhibit epigenetic changes, indicating that epigenetics might exert a pathogenic role in dementia. Epigenetic modifications are reversible and can potentially be targeted by pharmacological intervention. Epigenetic drugs may be useful for the treatment of major problems of health (e.g., cancer, cardiovascular disorders, brain disorders). The efficacy and safety of these and other medications depend upon the efficiency of the pharmacogenetic process in which different clusters of genes (pathogenic, mechanistic, metabolic, transporter, pleiotropic) are involved. Most of these genes are also under the influence of the epigenetic machinery. The information available on the pharmacoepigenomics of most drugs is very limited; however, growing evidence indicates that epigenetic changes are determinant in the pathogenesis of many medical conditions and in drug response and drug resistance. Consequently, pharmacoepigenetic studies should be incorporated in drug development and personalized treatments.
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5. [PDF] Metabolic slowdown as the proximal cause of ageing and death - bioRxiv
Aug 3, 2023 · We recently demonstrated how a specific maintenance system impeding overactivity disorders such as cancer might undergo positive selection while ...
6. Muscle weakness in the elderly: role of sarcopenia, dynapenia, and ...
Missing: cure
Aging is a multifactorial process leading to changes in skeletal muscle quantity and quality, which cause muscle weakness and disability in the aging population. This paper discusses the reasons for muscle weakness—and its biological and physiological mechanisms—in the elderly and describes the role of sarcopenia and dynapenia, and the possibilities to modify the age-associated decline in muscle function and decelerate the development of muscle weakness and disability. Resistance and endurance training are effective measures of exercise therapy in the elderly, which improve muscle metabolism and thereby muscle function and life quality.
7. Sponsors of SENS5 | Rejuvenation Research - Mary Ann Liebert, Inc.
Aug 5, 2011 · The Circadian Clock Conducts Development in Mammals: Can Stopping It be a Means of Control Over Aging? 16:00, Hagai Yanai Beer-Sheva, Israel, Is ...
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8. [PDF] View PDF - JMIR Aging
Jul 5, 2022 · Conclusions: Web-based interventions appear to be as effective as print-based interventions. Both modes might help older individuals remain ...
9. (PDF) Anti-Aging Medicine: Myths and Chances - Academia.edu
Following this shift in medical research and practice, the traditional concept of ageing has also been challenged by the development of “anti-ageing medicine”, ...
Technological innovations and biotechnological findings are revolutionizing medicine and health care. Following this shift in medical research and practice, the traditional concept of ageing has also been challenged by the development of “anti-ageing
10. Cureus | The Effects of Resveratrol on Telomeres and Post Myocardial ...
Nov 14, 2020 · ... down to 44 studies. The database used was PubMed, and the keywords used are "Resveratrol", "Telomere", "Post Myocardial Infarction". All the ...
Post myocardial infarction (MI) remodeling is the term used to define the changes in cardiac musculature after sustaining an ischemic injury. These changes decrease myocardial function and ultimately lead to heart failure. We review the contributing factors to post-MI remodeling, its association with telomere biology, as well as a myriad of other factors affecting aging and telomere length in relation to cardiovascular health. The main focus is on the effects of resveratrol in the cardiovascular system and its potential for therapeutic use in preventing long-term cardiovascular morbidity and mortality. We tried to answer important questions regarding the potential for resveratrol as a therapeutic drug to prevent adverse post-MI remodeling. In our search, we gathered 62 studies and narrowed our data down to 44 studies. The database used was PubMed, and the keywords used are "Resveratrol", "Telomere", "Post Myocardial Infarction". All the studies were carefully screened for relevant articles regarding our topic manually, Articles related to a positive association between resveratrol and its anti-aging, cardioprotective effects have been included in our study, as we could not find any articles in our search which showed a negative correlation. Our review concluded that resveratrol had pro-telomerase effects which could counter the development of adverse post-MI remodeling. Therefore resveratrol could be a useful therapeutic add-on drug to prevent cardiovascular disease. It is essential that further research including observational and large-scale clinical trials should be conducted to increase our understanding of the efficacy and viability of these novel therapeutic interventions.
11. More than a medical condition: Qualitative analysis of media ...
Aug 7, 2020 · Interestingly, science was expected to find a cure not only for dementia but also for old age. ... slow down aging but the consequences would be ...
The aim of our research is to explore how Alzheimer’s disease and dementia are represented in the Slovak media. Data consisted of text documents from the Newton media database. Search criteria included TV, radio, print and web sources that mentioned the words “Alzheimer” and “dementia” between 2015 and 2018. A thematic discourse analysis was applied in order to identify the themes and their mutual semantic relations. The analysis was focused primarily on the headlines ( n = 227). The results show that the biomedical perspective currently dominates at the expense of a socio-psychological one. Persons with Alzheimer’s disease and dementia are represented as tragic cases and victims of a cruel disease. Responsibility for care and prevention is individualized. Our findings suggest that a new perspective is needed. Such an approach should recognize the dignity and humanity of persons with Alzheimer’s disease and dementia despite their cognitive deficits and respect their socio-psychological needs.
12. [PDF] Analyses prospectives de mortalité: approches actuarielle et biomédicale
Nov 12, 2018 · This new approach may lead to a development of new effective remedies that could slow down or even reverse skin aging. Jane Schastnaya ...
13. [PDF] Care Robots for an Over-Aging Society
VDC was selected for the research study which is representative of most of the rural village development ... concept is that the aged people could be each other's ...
14. [PDF] Anti-ageing medicine - Research Collection - ETH Zürich
A ROBOT suit has been developed that could help older people or those with ... get worse if effective anti-ageing treatments were developed. Anti-ageing.
15. [PDF] The influence of ageing and object properties on prehension
As yet, however, little systematic research exists on the effects of object properties on older adults' reach-‐to-‐grasp performance. This thesis addresses that ...
16. [PDF] Can Pension Funds Partially Manage Longevity Risk by Investing ... - MDPI
Jul 2, 2018 · down human aging but also to restore youthful characteristics to the body once old. ... find enough investors to have enough drug development ...
17. [PDF] The Effects of Resveratrol on Telomeres and Post Myocardial ...
Nov 14, 2020 · cardiovascular aging and the decelerating effect of antioxidants prior to birth on the developmental programming of cardiovascular diseases ...
18. age relative risk: Topics by Science.gov
Age-related maculopathy (ARM) is the leading cause of blindness in the elderly. Although beneficial therapeutic strategies have recently begun to emerge, much ...
19. [PDF] Developing a Service Platform for Health and Wellbeing in a Living ...
on human capabilities, which is the freedom or effective opportunities people ... group and argued that the platform would be most beneficial for elderly people ...